1 edition of Pharmacology of purine and pyrimidine receptors found in the catalog.
Pharmacology of purine and pyrimidine receptors
Kenneth A. Jacobson
|Statement||edited by Kenneth A. Jacobson and Joel Linden|
|Series||Advances in pharmacology -- v. 61, Advances in pharmacology (En ligne) -- v. 61.|
|LC Classifications||QP801.P8 P48 2011eb|
|The Physical Object|
|Format||[ressource e lectronique] /|
|Pagination||1 online resource (1 texte e lectronique (xvi, 541 p.))|
|Number of Pages||541|
Cardiovascular Pharmacology (graduate textbook) baroreceptor reflex Chapter 6 blood pressure variability in Chapter 7 Chapter 8 carbon monoxide purine and pyrimidine receptors in cardiovascular pharmacology Chapter 9 myocardial ischemic preconditioning Chapter 10 apoptosis and cardiovascular disease Chapter 11 5 - serotonin 12th. The aim of this study was to characterize P2 receptors in the arterial vascular bed of human perfused placental cotyledons. Vasoconstrictor responses to bolus injections of purine and pyrimidine nucleotides were tested at basal tone, and vasodilator responses in preparations with tone raised by perfusion with prostaglandin F 2α (PGF 2α; 10–50n m).Cited by:
P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine nucleotides. To date, eight mammalian P2Y receptors are known (P2Y 1, P2Y 2, P2Y 4, P2Y 6, P2Y 11, P2Y 12, P2Y 13 and P2Y 14) as well as the non-mammalian chick p2y 3, Xenopus p2y 8 and turkey p2y receptors. p2y 9 and p2y 10 receptors are considered to be orphan receptors, and p2y 5 is now . The purine, pyrimidine, and folate antagonists represent a second group of cytotoxic drugs active against rapidly dividing or metabolizing cells. Included among these are the purine antagonists azathioprine and 6-mercaptopurine, the pyrimidine antagonist floxuridine, and the folate antagonist methotrexate.
P2Y receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on P2Y Receptors ) are activated by the endogenous ligands ATP, ADP, uridine triphosphate, uridine diphosphate and relationship of many of the cloned receptors to endogenously expressed receptors is not yet established and so it might be appropriate to use wording such as 'uridine triphosphate-preferring . Purine is a heterocyclic aromatic organic compound that consists of a pyrimidine ring fused to an imidazole ring. It is water-soluble. Purine also gives its name to the wider class of molecules, purines, which include substituted purines and their are the most widely occurring nitrogen-containing heterocycles in al formula: C₅H₄N₄.
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Edited by Kenneth A. Jacobson, Joel Linden. Vol Pages () Allosteric Modulation of Purine and Pyrimidine Receptors. https://doi. ISBN: OCLC Number: Description: xvi, pages: illustrations ; 24 cm. Contents: Structure of the adenosine receptors: implications for drug discovery --Adenosine receptors in health and disease --Adenosine and the regulation of metabolism and body temperature --Regulation of leukocyte function by adenosine receptors --Role of adenosine A₂[B] receptors.
Pharmacology of Purine and Pyrimidine Receptors by Joel Linden Other Kenneth A Jacobson Other. ebook. Sign up to save your library. With an OverDrive account, you can save your favorite libraries for at-a-glance information about availability.
Pharmacology of Purine and Pyrimidine Receptors. Adv Pharmacol. ;xv-xvi. doi: /B Pharmacology of purine and pyrimidine receptors. Preface. Jacobson KA, Linden by: 1. Review Purine and pyrimidine receptors G. Burnstock The pharmacology of the recombinant P2X receptor subtypes expressed in oocytes or other cell types is 2 G.
Burnstock Purine and pyrimidine receptors. consensus sequences for N-linked glycosylation. The P2X. The design of novel ligands for purine and pyrimidine receptors, in some cases based on a rational, structural approach, has resulted in selective receptor probes that promise to be useful in pharmacological studies.
These probes can display enhanced potency and/or selectivity, and in some cases stability, over previously used by: For example, both purine P2Y 1, 13 and pyrimidine P2Y 2 receptor subtypes have been positively correlated to neurite elongation, with the latter specifically linked to the α V integrin/Rho/ROCK pathway (del Puerto et al., ; Peterson et al., ).Cited by: Pharmacology of purine and pyrimidine receptors.
[Ken Jacobson; Joel Linden;] -- This is an overview of the fast-moving field of purinergic signalling through adenosine and ATP receptors. Authors are the leading authorities in their fields Subject matter is important for. Physiological, pharmacological and molecular biological data generated over the past three decades have demonstrated the existence of two major families of extracellular receptors, the P1, a family of four G-protein coupled receptors and the P2, a family of at least 12 receptors responsive to purine (ATP, ADP) and pyrimidine (UTP) nucleotides through which adenosine and ATP can function as.
Other purine and pyrrolidine nucleotides were either weakly depressant (inosine and guanosine derivatives) or largely inactive (xanthine, cytidine, thymidine, uridine derivatives). The 5′-triphosphates and to a lesser extent the 5′-diphosphates of all the purine and pyrimidines tested had excitant actions on cortical by: Adenosine 5′-triphosphate receptors have been cloned and characterised.
P1 receptors are selective for adenosine, a breakdown product of adenosine 5′-triphosphate after degradation by ectonucleotidases. Four subtypes are recognised, A 1, A 2A, A 2B and A 3 receptors. P2 receptors are activated by purine and by pyrimidine by: 4.
Pharmacology of Purinergic Receptors - authorSTREAM Presentation. Purine receptors P1 receptors P2 receptors (Adenosine receptor) (ATP receptors) (subtypes A1, A2 and A3) (subtypes P2X and P2Y) Classification: 6 All are member of GPCRs superfamily activated by both purine and pyrimidine nucleotides.
Subtypes: Only five mammalian. The P2Y6 receptor is a cytoprotective G-protein-coupled receptor (GPCR) activated by UDP (EC50 = μM). We compared and combined modifications to enhance P2Y6 receptor agonist selectivity, including ribose ring constraint, 5-iodo and 4-alkyloxyimino modifications, and phosphate modifications such as α,β-methylene and extension of the terminal phosphate group into γ-esters of UTP by: These novel receptors have close homology with the P 2U receptor and, whilst both are sensitive to UTP, one appears to be totally insensitive to purine nucleotides (Communi et al., ; Nguyen et al., ) whereas the other is activated only by extremely high concentrations of ATP (Chang et al., ).
These molecular studies have, therefore Cited by: Purine and pyrimidine nucleotide (P2) receptors | There is rapidly growing interest in receptors for ATP, ADP, UTP, UDP and other nucleotides. of the functional pharmacology of P2X receptor. The P2Y6 receptor is a cytoprotective G-protein-coupled receptor (GPCR) activated by UDP (EC50 = μM).
We compared and combined modifications to enhance P2Y6 receptor agonist selectivity, including ribose ring constraint, 5-iodo and 4-alkyloxyimino modifications, and phosphate modifications such as α,β-methylene and extension of the terminal phosphate group into γ-esters of UTP Cited by: Besides their intracellular metabolic and genetic roles, purine nucleotides and nucleosides constitute important extracellular signaling molecules.
Adenosine 5’-triphosphate (ATP) and adenosine, tightly controlled by nucleotidases and transporters, signal through a rich array of purinergic receptors. These receptors, which emerged early in evolution, are among the most abundant in living organisms.
Product Type: Book Edition: 1 First Published: Paperback: P1 and P2 Purine and Pyrimidine Receptor Ligands. and pharmacology have resulted in the identification of a number of novel ligands that have been used .Product Information.
Physiological, pharmacological and molecular biological data generated over the past three decades have demonstrated the existence of two major families of extracellular receptors, the P1, a family of four G-protein coupled receptors and the P2, a family of at least 12 receptors responsive to purine (ATP, ADP) and pyrimidine (UTP) nucleotides through which adenosine and.